10 Famous People with Klinefelter Syndrome: Number 1 & 7 Is Shocking (2024)

Klinefelter syndrome is one of the most popular chromosomal conditions affecting children, especially males. Approximately 1 in about 500 to 800 male children are born with this disorder yearly.

In the United States of America, over 3000 male children are born with this extra X chromosome every year. And almost 3 percent of the infertile males in the country suffer from Klinefelter syndrome.

Continue reading as we discuss the 10 famous individuals who have or had Klinefelter syndrome. But first, let’s find out more about this disease.

What Is Klinefelter Syndrome?

Klinefelter syndrome (KS) is a genetic disorder whereby a male child is born with an extra X chromosome in his cells. This disorder only affects male children.

Klinefelter contributes to infertility in men. It can also impede intellectual and physical development in men.

Surprisingly, this disease has no cure. One has to carry the extra X chromosome for life. However, medical professionals might treat most of the health problems associated with this chromosomal condition, if necessary.

The treatment often includes testosterone replacement therapy. Health professionals may also recommend language or speech therapy during childhood to assist affected children achieve the right speech development.

Is Klinefelter Syndrome Life-threatening?

A report published in theJournal of Clinical Endocrinology and Metabolismsuggested that Klinefelter Syndrome (KS) could increase a person’s mortality rate by 40 percent. This correlates with other reports that KS may reduce life expectancy by two years.

Those who participated in the research included KS patients and a control group of healthy individuals.

At the end of the study, researchers discovered that the increased mortality rates among KS patients were caused by infectious, circulatory, pulmonary, neurological, and urinary tract diseases.

However, what researchers don’t know yet is whether the disease itself (Klinefelter Syndrome) is responsible for the conditions that increased the mortality rate in KS patients. Further studies are necessary to understand the link between KS and the diseases mentioned above.

So, the mortality rate among KS patients and the primary cause of death are still unknown. Surprisingly, the world is yet to pay full attention to KS, a disease considered the most prevalent sex chromosome disorder in the world.

What Individuals With Klinefelter Syndrome Looks Like

KS has symptoms, which can help identify teenagers or adult males with the disease.Remember this condition can only affect males. Klinefelter people also have the appearance of a female. That makes it easier for many of them to do sex reassignment surgeries.

So, here are symptoms of Klinefelter syndrome in people, from babies to adults.

Symptoms of Klinefelter Syndrome in babies:

  • Delay speech
  • Weak muscles
  • Slower motor development
  • The testicl*s may take time to enter the scrotum when the baby is born.

Symptoms of Klinefelter in teenagers:

  • Weak bones
  • Small penis size
  • Has lower energy levels
  • Taller than average height
  • Less body and facial hair after puberty
  • Have issues with spelling, math, reading, or writing
  • Short torso, longer legs, and broader hips than in other boys in the same age bracket.

Symptoms of Klinefelter in the adult male:

  • Weak bones
  • Lower sex drive
  • Low or no sperm count
  • Increase in belly fat
  • Decreased body and facial hair
  • Taller than the average height

So these are the symptoms of KS. Now let’s look at famous individuals that had or have KS.

Famous Individuals With Klinefelter Syndrome

Here’s a list of people who had KS.

1. Tom Cruise:

At the age of seven, Tom cruise was diagnosed with dyslexia, a disorder that affects a child’s ability to develop a strong understanding of a language. Tom claimed that he tries to concentrate and read. But by the time he finish reading a passage, he forgets everything.

The actor even described himself as a “functional illiterate,” which was surprising, given how he performs on movie scenes. Now has overcome this disorder to become one of the most successful actors in Hollywood.

Today, Tom can’t read because of his condition. He instead memorizes his lines by listening to them on audiotape.

However, many people still claim that Tom has Klinefelter. Why? The reason is that his three kids are not his biological children.And yes, KS makes men impotent.

2. Lili Elbe, formerly known as Einar Andrea Magnus Wegener

Lili Elbe was a famous Danish painter and a transgender person. Lili’s birth name was Einar Andrea Magnus Wegener and he (Now a she) was among the first recipient of sex reassignment surgery in 1931.

Though not specified by the painter himself, a lot of people believed Einar Andrea had Klinefelter syndrome. The reason was that he had a feminine-looking face, legs, and body shape.

3. Jamie Lee Curtis:

Hollywood actress, Jamie Lee, is another notable personality who rumor mongers believed had Klinefelter syndrome. According to the rumors, Jamie Lee’s parents gave her a unisex name. And the reason was so he won’t have to do a name change for any gender he chooses later in life.

Jamie Lee hasn’t openly stated that he had Klinefelter syndrome. Even in all his interviews, he tries to dodge the question.

However, Jamie Lee’s feminine look gave him away as a Klinefelter syndrome patient. There are also rumors that he had received sex reassignment surgery. Now you can see that she dresses and does her thing like a female.

4. Janet Mock Formerly Known as Charles:

Janet Mock was born a male, but thanks to surgery, he’s now a female. Janet is a famous TV producer and writer.

Even though the now-famous transgender rights activist has always declined to comment on her genitalia, her physical features are enough evidence that she has Klinefelter syndrome.

Charles’s (now Janet) facial look, legs, hands, and body shape gave him away as a KS.

5. Lauren Foster:

Born December 1957, Lauren Foster is another celebrity with Klinefelter syndrome. She is a South African model who got disqualified while contesting for Miss South Africa. Lauren has also modeled in other parts of the world.

Lauren Foster is now a transgender person though she was born as a man.It was so obvious that she was a KS person.

6. Caroline Cossey:

Without being told, you can tell that Caroline had Klinefelter syndrome. He (now a female) had a female’s face, though born and raised a male. Caroline is also taller than the average height, a common symptom of KS.

The English model has now undergone surgery to become a female. And one thing people love about Caroline is that never shy of mentioning how she got bullied years back by peers because of her looks.

7. George Washington:

George is a very familiar name in American politics. He was a military general and the first president of the United States of America.

Though not documented, there were speculations that he had Klinefelter syndrome. The first reason was due to George Washington’s infertility. He had two children with his gorgeous wife, Martha. But we all know that he adopted those two children.

So, George Washington was unable to father a child in his lifetime. And that is a symptom seen in individuals with Klinefelter syndrome.

George’s unusual physical structure is another possible reason why many claimed he had this disability. He was 6 feet and 2 inches. So you can see that he was a tall person.

8. Brooke Moore, formerly known as Bradley:

To many people, she’s Brooke Moore. But do you know she wasn’t born a female? Brooke Moore was born a male, and he (Sorry, now she) attended an all-boys school.

At the age of 13, Brooke began to develop breasts. Doctors later diagnosed that he had Klinefelter syndrome. He also didn’t develop facial hair or Adam’s apple.

9. Caster sem*nya:

sem*nya is one athlete the Olympic community will never forget in a hurry. She won the 800m race at the 12th IAAF World Athletic Championship organized in Berlin, setting a world record in the process.

A lot of people questioned sem*nya’s sexuality following her landmark victory at the competition. And her masculine appearance was the focal point. It made many people believe she had Klinefelter syndrome.

10. Renee Richards:

Doctor Renee Richards is another famous personality diagnosed with Klinefelter syndrome. But what’s interesting about this popular ophthalmologist’s story is how she became famous despite her disability.

In 1976, she was barred from contesting in the single women’s tournament because of the law that required participants to have just two chromosomes. Nevertheless, Renee appealed the decision, won and had a blissful career afterwards.

Conclusion

Today, there are many people in the world with Klinefelter syndrome. Some are even celebrities and notable personalities. Most of them have decided to keep their condition private for reasons best known to them.

So, we can only speculate and analyze via their physical features. The facial look, legs, hands, body shape and fertility can help you identify someone with Klinefelter syndrome to some degree.

However, the public also needs to understand that KS is a genetic disorder. Individuals suffering it didn’t choose to have the disease. It developed from birth and has no cure.

So, instead of mocking and bullying people with KS in schools and other gatherings because of their facial appearance or body shape, shower them with love. We all deserved to be loved.

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10 Famous People with Klinefelter Syndrome: Number 1 & 7 Is Shocking (2024)

FAQs

Who are some famous people with Klinefelter syndrome? ›

10 famous people with Klinefelter syndrome
  • George Washington. George Washington, the first president of the United States 1789-97. ...
  • Lili Elbe. Lili Elbe (1886-1931). ...
  • Castor sem*nya. ...
  • Tom Cruise. ...
  • Janet Mock. ...
  • Lauren Foster. ...
  • Caroline Cossey. ...
  • Jaime Lee Curtis.
Jan 23, 2023

Does Adele have Klinefelter syndrome? ›

Adele was called back a week later to get the results and was shocked by the news. 'The doctor explained I had something called Klinefelter's syndrome, which meant that I wasn't really male, or female, but 'Intersex" - a mix of both.

How intelligent are people with Klinefelter syndrome? ›

Klinefelter's syndrome individuals have a below average IQ, typically between 80 and 90. However, only about 25% have any degree of mental retardation, and it is usually mild. Klinefelter's syndrome boys tend to have dyslexia and other learning disabilities.

What are 2 interesting facts about Klinefelter syndrome? ›

Klinefelter syndrome results when a boy is born with at least 1 extra X chromosome. This is written as XXY. Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

Do people with Klinefelter syndrome look different? ›

Decreased facial and body hair. Less muscular compared with other men. Enlarged breast tissue. Increased belly fat.

What disabilities do people with Klinefelter syndrome have? ›

Children with Klinefelter syndrome may have low muscle tone (hypotonia) and problems with coordination that may delay the development of motor skills, such as sitting, standing, and walking.

Is Klinefelter Autism? ›

Neurodevelopmental concerns in males with sex chromosome aneuploidy (SCA) (XXY/Klinefelter syndrome, XYY, and XXYY) include many symptoms seen in autism spectrum disorder (ASD), such as speech-language impairment, verbal cognitive deficits, and social difficulties.

Why are Klinefelter patients tall? ›

From early school age, boys with Klinefelter syndrome tend to be taller (increased leg length) in part because testosterone (via conversion to oestrogen) normally stops the long bones from growing after puberty. This increase in height is maintained throughout life.

Do people with Klinefelter have armpit hair? ›

Other symptoms associated with Klinefelter syndrome include abnormal body proportions; abnormally large breasts; less than normal amount of pubic, armpit, and facial hair; attention deficient hyperactivity disorder; depression; learning disabilities; lung disease and varicose veins.

Are Klinefelter people tall? ›

Adults with Klinefelter syndrome are usually taller than nonaffected adult males, reaching a mean final height of about 185 cm (73 in). XXY males (see the image below) also have disproportionately long arms and legs.

Does Klinefelter have mental retardation? ›

Klinefelter syndrome (KS) has not typically been associated with mental retardation (MR), however, in recent years a growing body of evidence suggested that KS boys often experience language deficits and academic difficulties.

What is everyday life like with Klinefelter syndrome? ›

Boys with Klinefelter syndrome may have difficulty with spelling, reading, writing, and paying attention. They may tend to be quiet, shy, and more reserved or sensitive than other guys. Some boys with Klinefelter syndrome are less interested in sports or physical activities.

What are 3 characteristics of Klinefelter syndrome? ›

Typically, a male has one X and one Y chromosome. People with Klinefelter syndrome can experience breast growth, breast cancer, osteoporosis, infertility and learning difficulties. Treatment typically involves physical and emotional therapy, as well as hormone replacement.

What part of the body does Klinefelter syndrome affect? ›

Klinefelter syndrome is caused by an additional X chromosome. This chromosome carries extra copies of genes, which may interfere with the development of the testicl*s and mean they produce less testosterone (male sex hormone) than usual.

What is the diet for Klinefelter syndrome? ›

No special diet is required for KS although a well balanced diet is important. It is important to ask the parents about the medical issues in their child and what medical management challenges they may face at school. Many boys with Klinefelter are followed by an endocrinologist when they reach the age of puberty.

What are the behavioral symptoms of Klinefelter syndrome? ›

In general, individuals with below average scores show learning difficulties in specific areas of verbal and executive tasks. Delayed speech, slower than average problem-solving abilities, impulsiveness, reduced attention span, memory problems and possibly dyslexia and autism have been reported.

What is the body shape of a person with Klinefelter syndrome? ›

The phenotype of the affected person is basically male, tall stature with elongated lower legs and forearms. The body shape, however, is more feminine (narrow shoulders, broad hips) with a lower muscle mass.

What color is Klinefelter syndrome? ›

A man with Klinefelter syndrome (47, XXY) is red-green color blind, which is an X-linked recessive disorder.

What cancers are associated with Klinefelter syndrome? ›

Klinefelter's syndrome is associated with an increased risk of developing lung cancer, breast cancer, and non-Hodgkin lymphoma, and with a lower risk of prostate cancer, reports a UK study (J Natl Cancer Inst 2005; 97: 1204–10).

What is the life expectancy of someone with Klinefelter syndrome? ›

Prognosis for Klinefelter Syndrome

In general, life expectancy is normal. Some research has found that life expectancy for men with the condition may be a year or two less than those without it because of other health problems linked to Klinefelter.

Can Klinefelter syndrome cause ADHD? ›

Furthermore, research suggests that males with XXY experience heightened rates of attention-deficit/hyperactivity disorder (ADHD; Bruining, Swaab, Kas, & van Engeland, 2009), a disorder that is also associated with EF difficulties (Barkley, 1997).

Is Klinefelter syndrome a Down syndrome? ›

In both Klinefelters and Downs syndromes, there are 47 chromosomes instead of normal 46. But, Klinefelters syndrome is a sex chromosome abnormality, whereas Downs syndrome is an autosomal abnormality.

Is Klinefelter syndrome a form of Down syndrome? ›

In conclusion, Down–Klinefelter's syndrome is a rare chromosomal abnormality. Patient present with physical characteristics of Down's syndrome at birth and Klinefelter's syndrome features at during puberty. It is important to counsel families about recurrence risk for future pregnancies.

Does Klinefelter syndrome affect teeth? ›

The X chromosome has been linked to enamel thickness as well as the rate of dental development (2, 16, 32, 39, 44-46). Consequently, males affected by KS have larger teeth than males with a normal chromosomal complement (19, 32, 36, 44, 47-49).

Do people with Klinefelter go bald? ›

Baldness was reported in 19% (20 out of 104) patients of KS with a mean age of 45 in a large study [10].

Does Klinefelter syndrome affect the brain? ›

Klinefelter syndrome has increased brain responses to auditory stimuli and motor output, but not to visual stimuli or Stroop adaptation.

Does Klinefelter syndrome affect mental health? ›

Deficits in social engagement is characteristic of patients with KS, including deficits in attention switching, imagination, communication and general social skills[20;31], which may help explain KS patients' increased risk of mental illness in general, and anxiety and depression in particular.

What are the two characters of a person with Klinefelter syndrome? ›

Persons with this disorder are sterile males. Symptoms of Klinefelter syndrome are undeveloped testes, sparse body hair, feminine pubic hair, and some degree of breast development. Other symptoms that show up include long limbs, knock knees, and mental retardation.

What medication is used to treat Klinefelter? ›

How is Klinefelter syndrome treated? Males with Klinefelter syndrome can be given testosterone, a hormone needed for sexual development. If treatment is started around the age of puberty, it can help boys with the sexual development of their bodies. Testosterone is given by injection or through a skin patch or gel.

Is Klinefelter syndrome intersex? ›

XXYs are not intersexed, defined as a condition where the phenotype expression [physical appearance] of primary sexual characteristics is at variance with one's genetic sex….

Which parent is responsible for Klinefelter's syndrome? ›

Klinefelter syndrome is not caused by anything the parents did or did not do. The disorder is a random error in cell division that happens when a parent's reproductive cells are being formed.

Who is most likely to get Klinefelter syndrome? ›

Klinefelter syndrome occurs in about 1 out of 500 to 1,000 baby boys. Women who get pregnant after age 35 are slightly more likely to have a boy with this syndrome than younger women.

What serial killers have XYY syndrome? ›

STUDIES SOON BEGAN TO APPEAR, AND IT WAS LATER DISCOVERED THAT SOME OF SOCIETY'S MOST NOTORIOUS MURDERERS (E.G., ROBERT PETER TAIT, DANIEL HUGON, JOHN FARLEY) HAD THE EXTRA Y CHROMOSOME.

Are people with Klinefelter syndrome tall? ›

Adults with Klinefelter syndrome are usually taller than nonaffected adult males, reaching a mean final height of about 185 cm (73 in). XXY males (see the image below) also have disproportionately long arms and legs. About 25% of patients have fifth-finger clinodactyly.

Is Superman syndrome a real thing? ›

Superman syndrome, also known as 47, XYY, is a condition classified as a chromosomal aneuploidy (which is an abnormality in chromosome structure and/or number) in which males have an additional Y chromosome.

Can men with XYY have kids? ›

Most individuals with 47,XYY syndrome have normal production of the male sex hormone testosterone and normal male sexual development, and they are usually able to father children.

What do people with XYY look like? ›

taller than average height. low muscle tone, or muscle weakness (called hypotonia) very curved pinky finger (called clinodactyly) widely spaced eyes (called hypertelorism)

Is Klinefelter from mom or dad? ›

Klinefelter syndrome is not directly inherited – the additional X chromosome occurs as a result of either the mother's egg or the father's sperm having the extra X chromosome (an equal chance of this happening in either), so after conception the chromosome pattern is XXY rather than XY.

Do people with Klinefelter have body hair? ›

Many men who have Klinefelter syndrome do not have obvious symptoms. Others have sparse body hair, enlarged breasts, and wide hips.

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